The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experimentally demonstrate a novel nanostructured coverslip that converts phase information to high-contrast intensity images. This compact device enables real-time, all-optical generation of pseudo three-dimensional images of phase objects on transmission. We show that by placing unstained human cancer cells on the device, the internal structure within the cells can be clearly seen. Our research demonstrates the significant potential of nanophotonic devices for integration into compact imaging and medical diagnostic devices.

The nanophotonics enhanced coverslip (NEC) enables ultra-compact phase imaging of samples placed directly on top of the device. Visualisation of artificial phase objects and unstained biological cells is demonstrated.

中文翻译：

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纳米光子学增强了盖玻片的生物学相位成像

可视化透明物体（例如活细胞）的能力对于理解生物学过程至关重要。在这里，我们通过实验证明了一种新颖的纳米结构盖玻片，可将相位信息转换为高对比度强度图像。这种紧凑的设备可以在传输时实时全光学生成相位对象的伪三维图像。我们显示通过将未染色的人类癌细胞放置在设备上，可以清楚地看到细胞内的内部结构。我们的研究表明，纳米光子器件具有集成到紧凑型成像和医学诊断设备中的巨大潜力。

纳米光子学增强盖玻片（NEC）可以对直接放置在设备顶部的样品进行超紧凑相成像。展示了人造相物体和未染色生物细胞的可视化。