Solvent application in industrial processes is inevitable due to its required role in dissolving solutes, promoting mass and heat transfer, and facilitating separation and purification processes. Notably, woody plants have a high degree of fibrosis and lignification with a mass transfer barrier effect from their multi-scale structure and complex component effects, which makes it difficult for solvents to seep into these plant cells. An ultrasound-assisted complete extraction in ionic liquid non-aqueous solvent system (UACE-ILNAS) method was successfully designed and applied to achieve excellent extraction of five alkaloid components (berberine, palmatine, jatrorrhizine, magnoflorine and phellodendrine) from the bark and leaves of Phellodendron amurense Rupr. From single-factor design and response surface methodology (RSM), the significant factors affecting the average yield of the alkaloids, the ionic liquid concentration, liquid-solid ratio and ultrasonic irradiation temperature, were optimized. Under the optimal conditions, the average yields of the alkaloids from the bark and leaves of P. amurense were 4.22 ± 0.20 and 2.47 ± 0.12 mg/g, respectively, which were highly consistent with the response surface optimization and kinetics analysis results. The non-aqueous aprotic solvent dimethyl sulfoxide (DMSO) was innovatively used as a co-solvent for the ionic liquid [C₄mim][OAc]. The DMSO plays a positive role in promoting penetration, helping cell wall dissolve, reducing viscosity, etc. The proposed method overcomes the poor water solubility of isoquinoline alkaloids and the negative effects from the high viscosity of ionic liquids to effectively guarantee the alkaloid quality and yield. In addition, ultrasound plays a reinforcing role in achieving full extraction. Therefore, the developed method shows good application prospects for the separation of low-polarity constituents, especially those present in woody plants.

溶剂在工业过程中的应用是不可避免的，因为它在溶解溶质，促进传质和传热以及促进分离和纯化过程中起着必不可少的作用。值得注意的是，木本植物由于其多尺度结构和复杂的成分效应而具有高度的纤维化和木质化，并具有传质阻挡作用，这使得溶剂很难渗入这些植物细胞中。成功设计并应用了超声辅助的离子液体非水溶剂系统完全萃取方法（UACE-ILNAS），以实现从树皮和叶片中五个生物碱成分（小ber碱，棕榈碱，麻疯子碱，厚朴碱和黄柏树碱）的优异萃取。黄柏鲁普 通过单因素设计和响应面方法（RSM），优化了影响生物碱平均收率，离子液体浓度，液固比和超声辐照温度的重要因素。在最佳条件下，紫花槐树皮和叶片生物碱的平均产量分别为4.22±0.20和2.47±0.12mg / g，与响应面优化和动力学分析结果高度吻合。非水非质子传递溶剂二甲亚砜（DMSO）被创新地用作离子液体[C ₄mim] [OAc]。DMSO在促进渗透，帮助细胞壁溶解，降低粘度等方面起着积极作用。该方法克服了异喹啉生物碱的水溶性差和离子液体高粘度带来的负面影响，从而有效地保证了生物碱的质量和产量。 。另外，超声在实现完全提取中起着增强的作用。因此，所开发的方法在分离低极性成分，尤其是木本植物中存在的低极性成分方面显示出良好的应用前景。