Aims/hypothesis

Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear in diabetic patients.

Methods

This cross-sectional study was designed to investigate the correlations among pancreatic volume (PV) based on computed tomography, IGF-1 levels, age- and sex-adjusted IGF-1 levels (IGF-1 Z-score), and C-peptide levels in patients with type 1 diabetes (T1D) (n = 51) and type 2 diabetes (T2D) (n = 104) in a Japanese population.

Results

PV was significantly correlated with body weight (BW) in both types of diabetes. PV adjusted for BW (PV/BW), IGF-1 Z-score and C-peptide levels were significantly lower in patients with T1D than T2D. There was a significant positive correlation between C-peptide levels and PV/BW in both subtypes of diabetes. IGF-1 Z-scores were significantly correlated with PV/BW in patients with T1D (r = 0.37, P = 0.007), but not T2D. Although IGF-1 Z-scores were not correlated with age, age of disease onset, disease duration, HbA1c, or C-peptide levels in both types of diabetes, a multivariable liner regression analysis revealed that IGF-1 Z-score and C-peptide levels were independent correlates of PV/BW in T1D patients, while C-peptide levels were a sole correlate in T2D.

Conclusions/interpretation

Decreased IGF-1 levels might be one causal factor for smaller pancreas in patients with T1D.

中文翻译：

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胰岛素样生长因子 1 与 1 型和 2 型糖尿病患者胰腺体积之间的关联：日本人群的横断面研究

目标/假设

尽管已知 IGF-1 可促进器官生长，包括外分泌胰腺，但糖尿病患者血浆 IGF-1 水平与胰腺大小之间的关联仍不清楚。

方法

这项横断面研究旨在调查基于计算机断层扫描的胰腺体积 (PV)、IGF-1 水平、年龄和性别调整的 IGF-1 水平（IGF-1 Z评分）和 C 肽之间的相关性日本人群中 1 型糖尿病 (T1D) ( n  = 51) 和 2 型糖尿病 (T2D) ( n  = 104) 患者的水平。

结果

在两种类型的糖尿病中，PV 与体重 (BW) 显着相关。T1D 患者的PV (PV/BW) 调整后的 BW、IGF-1 Z评分和 C 肽水平显着低于 T2D 患者。在两种糖尿病亚型中，C 肽水平与 PV/BW 呈显着正相关。IGF-1 Z分数与 T1D 患者的 PV/BW 显着相关（r  = 0.37，P  = 0.007），但与 T2D 无关。虽然 IGF-1 Z评分与两种糖尿病的年龄、发病年龄、病程、HbA1c 或 C 肽水平无关，但多变量线性回归分析显示 IGF-1 Z- 评分和 C 肽水平是 T1D 患者 PV/BW 的独立相关因素，而 C 肽水平是 T2D 患者的唯一相关因素。

结论/解释

IGF-1 水平降低可能是 T1D 患者胰腺变小的原因之一。