We examined whether a polygenic score (PGS) for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits at multiple time points in adolescence (ages 11, 14, and 17 years; N = 3,225). The smoking PGS had strong associations with the stable variance across time for all the externalizing measures (mean standardized β = 0.27), agreeableness (β = −0.22, 95% confidence interval [CI] = [−0.28, −0.16]), and conscientiousness (β = −0.19, 95% CI = [−0.24, −0.13]) but was not significantly associated with internalizing measures (mean β = 0.06) or extraversion (β = 0.01, 95% CI = [−0.05, 0.07]). After controlling for smoking at age 17 years, the associations with externalizing, low agreeableness, and low conscientiousness remained statistically significant. The smoking PGS measures genetic influences that contribute to a spectrum of phenotypes related to behavioral disinhibition, including externalizing psychopathology and normal-range personality traits related to behavioral control but not internalizing psychopathology.

我们通过评估吸烟的多基因评分 (PGS) 与青春期多个时间点（11、14 和 17 岁；N = 3,225）的外化和内化精神病理学以及相关人格特征的关联，来检验吸烟的多基因评分 (PGS) 是否可以测量一般行为去抑制的遗传风险。 ）。吸烟 PGS 与所有外化指标（平均标准化 β = 0.27）、宜人性（β = -0.22，95% 置信区间 [CI] = [-0.28，-0.16]）和随时间变化的稳定方差有很强的相关性。责任心（β = -0.19，95% CI = [-0.24，-0.13]），但与内化措施（平均β = 0.06）或外向性（β = 0.01，95% CI = [-0.05，0.07]）没有显着相关）。在 17 岁时控制吸烟后，与外化、低宜人性和低责任性的关联仍然具有统计学意义。吸烟 PGS 测量遗传影响，这些影响导致与行为去抑制相关的一系列表型，包括与行为控制相关的外化精神病理学和正常范围的人格特征，但不包括内化精神病理学。