Smart and Functionalized Development of Nucleic Acid-Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges,Advanced Science

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Smart and Functionalized Development of Nucleic Acid-Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-07 , DOI: 10.1002/advs.202100216
Yangzi Zhang ₁ , Longjiao Zhu ₁ , Jingjing Tian ₁ , Liye Zhu ₁ , Xuan Ma ₁ , Xiaoyun He ₂ , Kunlun Huang _{1,

2,

3} , Fazheng Ren ₁ , Wentao Xu _{1,

2,

3}

Affiliation

Nucleic acid-based hydrogels that integrate intrinsic biological properties of nucleic acids and mechanical behavior of their advanced assemblies are appealing bioanalysis and biomedical studies for the development of new-generation smart biomaterials. It is inseparable from development and incorporation of novel structural and functional units. This review highlights different functional units of nucleic acids, polymers, and novel nanomaterials in the order of structures, properties, and functions, and their assembly strategies for the fabrication of nucleic acid-based hydrogels. Also, recent advances in the design of multifunctional and stimuli-responsive nucleic acid-based hydrogels in bioanalysis and biomedical science are discussed, focusing on the applications of customized hydrogels for emerging directions, including 3D cell cultivation and 3D bioprinting. Finally, the key challenge and future perspectives are outlined.

中文翻译：

基于核酸的水凝胶的智能和功能化开发：组装策略、最新进展和挑战

基于核酸的水凝胶整合了核酸的固有生物学特性及其先进组件的机械行为，对于开发新一代智能生物材料而言，对于生物分析和生物医学研究来说很有吸引力。它与新型结构和功能单元的开发和结合密不可分。本综述重点介绍了核酸、聚合物和新型纳米材料的不同功能单元的结构、性质和功能，以及它们用于制造基于核酸的水凝胶的组装策略。此外，还讨论了生物分析和生物医学领域多功能和刺激响应核酸水凝胶设计的最新进展，重点关注定制水凝胶在新兴方向的应用，包括3D细胞培养和3D生物打印。最后，概述了主要挑战和未来前景。

更新日期：2021-05-07

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