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Recent Advancements in Regenerative Approaches for Thymus Rejuvenation
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-07 , DOI: 10.1002/advs.202100543 Himal Sharma 1 , Lorenzo Moroni 1
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-07 , DOI: 10.1002/advs.202100543 Himal Sharma 1 , Lorenzo Moroni 1
Affiliation
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The thymus plays a key role in adaptive immunity by generating a diverse population of T cells that defend the body against pathogens. Various factors from disease and toxic insults contribute to the degeneration of the thymus resulting in a fewer output of T cells. Consequently, the body is prone to a wide host of diseases and infections. In this review, first, the relevance of the thymus is discussed, followed by thymic embryological organogenesis and anatomy as well as the development and functionality of T cells. Attempts to regenerate the thymus include in vitro methods, such as forming thymic organoids aided by biofabrication techniques that are transplantable. Ex vivo methods that have shown promise in enhancing thymic regeneration are also discussed. Current regenerative technologies have not yet matched the complexity and functionality of the thymus. Therefore, emerging techniques that have shown promise and the challenges that lie ahead are explored.
中文翻译：
胸腺再生再生方法的最新进展
胸腺通过产生多种 T 细胞来保护身体免受病原体侵害，从而在适应性免疫中发挥关键作用。疾病和毒性损伤等多种因素都会导致胸腺退化，导致 T 细胞输出减少。因此，身体容易遭受多种疾病和感染。在这篇综述中，首先讨论了胸腺的相关性，然后讨论了胸腺胚胎器官发生和解剖学以及 T 细胞的发育和功能。再生胸腺的尝试包括体外方法，例如借助可移植的生物制造技术形成胸腺类器官。还讨论了在增强胸腺再生方面显示出前景的离体方法。目前的再生技术尚未与胸腺的复杂性和功能相匹配。因此，我们对已显示出前景的新兴技术和未来的挑战进行了探讨。
更新日期：2021-05-07
中文翻译：
胸腺再生再生方法的最新进展
胸腺通过产生多种 T 细胞来保护身体免受病原体侵害，从而在适应性免疫中发挥关键作用。疾病和毒性损伤等多种因素都会导致胸腺退化，导致 T 细胞输出减少。因此，身体容易遭受多种疾病和感染。在这篇综述中，首先讨论了胸腺的相关性，然后讨论了胸腺胚胎器官发生和解剖学以及 T 细胞的发育和功能。再生胸腺的尝试包括体外方法，例如借助可移植的生物制造技术形成胸腺类器官。还讨论了在增强胸腺再生方面显示出前景的离体方法。目前的再生技术尚未与胸腺的复杂性和功能相匹配。因此，我们对已显示出前景的新兴技术和未来的挑战进行了探讨。
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