Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research-related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty-five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long-term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non-infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.

中文翻译：

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狒狒（狒狒）支气管败血博德特氏菌的口服、雾化和联合抗生素治疗的比较

尽管疫苗接种率很高，但百日咳的病原体百日咳博德特氏菌的发病率在全球一些人群中正在上升，并且正在进行重要的研究以解决这个问题。狒狒是百日咳研究的既定模型，但与许多哺乳动物一样，它们可以自然感染支气管败血博德特氏菌。因为B。 支气管败血症干扰B . 百日咳研究，必须将其排除在考虑参加百日咳研究的狒狒之外。除了与研究相关的问题外，B . 支气管败血症有时会导致狒狒和其他非人类灵长类动物出现临床疾病。这项研究检查了使用抗生素清除B . 支气管败血症在自然感染的狒狒中。将 35 只幼狒狒分为 5 个治疗组：口服磺胺甲恶唑/甲氧苄啶 (TMS)、雾化庆大霉素 (庆大霉素)、阳性动物联合用药 (TMS + 庆大霉素)、联合用药 (TMS + 庆大霉素) 作为暴露动物的预防剂和不用药。治疗（对照）。对阳性动物给予口服 TMS 和雾化庆大霉素的组合是最有效的，在 12 只治疗动物中的 11 只中产生长期清除。为避免不必要地使用抗生素，我们的主要管理策略是筛选和分离以允许自然清除并限制与未感染动物的接触，但本研究调查了可在特殊情况下使用的抗生素方案。