Phosphatidylethanolamine is a major component of phospholipids with both structural and metabolic functions in cells. Previous studies have revealed that phosphatidylethanolamine can modulate autophagy with a protective effect against age-related diseases. We examined the effect of dietary supplementation with phosphatidylethanolamine on stress response and aging in Caenorhabditis elegans. Phosphatidylethanolamine increased resistance to oxidative stress without effect on heat stress or ultraviolet irradiation. Both mean and maximum lifespans were significantly increased by phosphatidylethanolamine while fertility was reduced as a trade-off. Age-related decline of muscle function was delayed in animals treated with phosphatidylethanolamine. Supplementation with phosphatidylethanolamine suppressed toxic effect of amyloid β and high-glucose diet. Increased ROS levels and induction of stress-responsive genes after dietary supplementation with phosphatidylethanolamine suggest that anti-oxidative stress and anti-aging effects of phosphatidylethanolamine might be though hormesis. Genetic analysis using long-lived mutants and knockdown by RNAi revealed that the lifespan-extending effect of phosphatidylethanolamine overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16, a downstream transcription factor known to regulate the expression of many stress-responsive genes. These findings indicate that phosphatidylethanolamine has anti-oxidative stress and anti-aging activities with its underlying mechanisms involving hormesis and reduced insulin/IGF-1-like signaling in C. elegans.

磷脂酰乙醇胺是磷脂的主要成分，在细胞中具有结构和代谢功能。先前的研究表明，磷脂酰乙醇胺可以调节自噬，对与年龄相关的疾病具有保护作用。我们检查了膳食补充磷脂酰乙醇胺对秀丽隐杆线虫应激反应和衰老的影响. 磷脂酰乙醇胺增加了对氧化应激的抵抗力，而对热应激或紫外线照射没有影响。磷脂酰乙醇胺显着增加了平均寿命和最长寿命，而作为一种权衡，生育能力降低了。在用磷脂酰乙醇胺治疗的动物中，与年龄相关的肌肉功能下降被延迟。补充磷脂酰乙醇胺可抑制β淀粉样蛋白和高糖饮食的毒性作用。膳食补充磷脂酰乙醇胺后增加的 ROS 水平和诱导应激反应基因表明，磷脂酰乙醇胺的抗氧化应激和抗衰老作用可能是通过兴奋作用产生的。使用长寿突变体和 RNAi 敲低的遗传分析表明，磷脂酰乙醇胺的延长寿命作用与减少胰岛素/IGF-1 样信号传导的作用重叠，并且需要 DAF-16，一种已知可调节许多基因表达的下游转录因子应激反应基因。这些发现表明，磷脂酰乙醇胺具有抗氧化应激和抗衰老活性，其潜在机制涉及兴奋和减少胰岛素/IGF-1样信号传导。秀丽隐杆线虫。