The efficient and scalable synthesis of lanthanide-doped NPs, which exhibit down- and upconversion luminescent properties simultaneously, is still a main challenge that are hindering their adoption. Herein, we employed a facile method, i.e. reactive flash nanoprecipitation, to fabricate dual-mode luminescent lanthanide phosphate (LnPO₄) NPs: lanthanum phosphate (LaPO₄) co-doped with Tb³⁺ and Yb³⁺. The lanthanide source streams and phosphate ion source streams were efficiently mixed in a multi-inlet vortex mixer reactor, and the use of a stabilizer was found to facilitate the formation of uniformly-dispersed LnPO₄ nanocrystals. It is demonstrated that the annealed LnPO₄ NPs exhibited intense down- and upconversion emission under UV and NIR irradiation, respectively. Notably, through adjusting the LnPO₄ to stabilizer mass ratio, the NP diameter could be tuned in a range between 50 and 200 nm, and the composition of LaPO₄:Tb³⁺,Yb³⁺ NPs could be easily tuned by adjusting the flow rate ratio of the feed streams.

同时显示下转换和上转换发光特性的掺杂镧系元素的NP的有效和可扩展合成仍然是阻碍其采用的主要挑战。在本文中，我们采用了一种简便的方法，即反应性快速纳米沉淀法，来制备双模式发光镧系元素磷酸盐（LnPO ₄）NPs：共掺有Tb ³⁺和Yb ^3+的磷酸镧（LaPO ₄）。在多入口涡旋混合器反应器中有效地混合了镧系元素源流和磷酸根离子源流，发现使用稳定剂有助于形成均匀分散的LnPO ₄纳米晶体。结果表明，退火后的LnPO ₄在紫外线和近红外辐射下，NPs分别表现出强烈的下转换和上转换发射。值得注意的是，通过调节LnPO ₄与稳定剂的质量比，可以将NP直径调节在50至200 nm之间，并且通过调节流量可以很容易地调节LaPO ₄：Tb ³⁺，Yb ³⁺ NP的组成。进料流的比率。