Under normal physiological conditions, IGF-1 (insulin-like growth factor-1) has important biological effects. However, many studies have found that IGF-1 is closely related to the occurrence and development of breast cancer. But up to now, the cellular properties of IGF-1 have not been systematically explored in breast cancer cell. It is well-known that the cellular properties and behaviors of IGF-1/IGF-1R are closely related to its biological functions. In the current study, we used the breast cancer cell line as a model to explore the biological characteristics of IGF-1/IGF-1R, and found that IGF-1/IGF-1R can be internalized into the cytoplasm. In addition, we also found that IGF-1R can also enter cell nuclei under the mediation of IGF-1. Further research found that the nuclear-localized IGF-1R has important potential biological effects, which is closely associated to the proliferation of breast cancer cell, this may be achieved by regulating IGF-1R-mediated intracellular signaling. The current research has laid the foundation for investigating the relationship between IGF-1/IGF-1R system and the occurrence and development of breast cancer.

在正常生理条件下，IGF-1（胰岛素样生长因子-1）具有重要的生物学作用。然而许多研究发现IGF-1与乳腺癌的发生、发展密切相关。但迄今为止，IGF-1在乳腺癌细胞中的细胞特性尚未得到系统研究。众所周知，IGF-1/IGF-1R的细胞特性和行为与其生物学功能密切相关。在本研究中，我们以乳腺癌细胞系为模型，探讨IGF-1/IGF-1R的生物学特性，发现IGF-1/IGF-1R可以内化到细胞质中。此外，我们还发现IGF-1R在IGF-1的介导下也可以进入细胞核。进一步研究发现核定位的IGF-1R具有重要的潜在生物学效应，与乳腺癌细胞的增殖密切相关，这可能是通过调节IGF-1R介导的细胞内信号传导来实现的。目前的研究为探讨IGF-1/IGF-1R系统与乳腺癌发生、发展的关系奠定了基础。