On March 2019 the World Health Organization declared Coronavirus disease (COVID-19) pandemic. Several recent reports disclose that the outcome of the infection is related to age, sex and can be influenced by underlying clinical conditions. Parkinson's disease (PD) and other parkinsonisms are the most common chronic disease which can cause, directly or indirectly, the patient to be more exposed to other diseases, mostly respiratory system's ones. Our primary outcome is to evaluate if PD patients are more susceptible than non-PD to take COVID-19 infection. Second, to detect if the infection course is worse in PD-COVID+ patients versus non-PD. This is a retrospective observational study on a cohort of 18 patients (13 PD- 5 non-PD), hospitalized in a Rehabilitative Unit during the occurrence of SARS-CoV2 epidemic outbreak. All patients performed laboratory tests, lung Computed Tomography (CT) and have been tested for COVID-19 thorough pharyngeal swab. PD and non-PD groups were comparable for age, gender and Hoehn and Yahr stage. Seventy-seven (77)% of PD and 60% of non-PD resulted positive for COVID-19. PD-COVID+ and PD-COVID- did not differ for age, disease duration and L-dopa daily dose. PD COVID-19+ subjects were mainly asymptomatic (50%) while non-PD ones were all symptomatic, mostly with respiratory difficulties. PD doesn't seem to be a risk factor to take SARS-COV2 infection, even if our study is related to a limited sample size. Our results, together with those of other recent studies, highlight the need to evaluate the actual susceptibility of patients with Parkinson's disease to develop COVID-19 disease, and how the infection may influence the risk of clinical worsening and increase of mortality.

中文翻译：

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SARS-COV2 感染对住院护理的帕金森病或帕金森病患者的影响：临床病例系列研究。

2019 年 3 月，世界卫生组织宣布冠状病毒病 (COVID-19) 大流行。最近的几份报告披露，感染的结果与年龄、性别有关，并且可能受到潜在临床状况的影响。帕金森病（PD）和其他帕金森病是最常见的慢性疾病，可直接或间接导致患者更多地罹患其他疾病，主要是呼吸系统疾病。我们的主要结果是评估 PD 患者是否比非 PD 患者更容易感染 COVID-19。其次，检测 PD-COVID+ 患者的感染过程是否比非 PD 患者更严重。这是一项针对 SARS-CoV2 流行病爆发期间在康复科住院的 18 名患者（13 名 PD-5 非 PD）的回顾性观察研究。所有患者均进行了实验室检查、肺部计算机断层扫描 (CT)，并接受了彻底的咽拭子检测以进行 COVID-19 检测。PD 组和非 PD 组在年龄、性别以及 Hoehn 和 Yahr 分期方面具有可比性。七十七 (77)% 的帕金森病患者和 60% 的非帕金森病患者的 COVID-19 检测结果呈阳性。PD-COVID+ 和 PD-COVID- 在年龄、病程和左旋多巴日剂量方面没有差异。PD COVID-19+受试者主要无症状（50%），而非PD受试者均出现症状，大多伴有呼吸困难。即使我们的研究样本量有限，PD 似乎也不是感染 SARS-COV2 的危险因素。我们的结果以及其他最近的研究结果强调需要评估帕金森病患者发展为 COVID-19 疾病的实际易感性，以及感染如何影响临床恶化和死亡率增加的风险。