The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

---

较老的主观年龄与加速的表观遗传老化有关。

本研究调查了来自健康与退休研究的 2,253 名成人（平均年龄 = 67.40，SD = 8.17）的主观年龄与表观遗传时钟之间的前瞻性关联。主观年龄和人口统计因素在 2008/2010 年进行了评估，表观遗传时钟在 2016 年使用 DNA 甲基化 (DNAm) PhenoAge 进行了评估。回归分析表明，主观年龄较大与表观遗传老化加速有关；中介分析显示，自评健康和 CRP 解释了这种关联。研究结果表明，感觉比实际年龄大的人在生理上更老，部分原因是他们感知到的健康和炎症特征。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。