Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a physiological setting. In turn, the electronic properties and supramolecular chemistry of metal complexes can be exploited to characterize drug delivery nanosystems by NMR. The recent evolution of in-cell NMR methodology is presented with special emphasis on metal-related processes. Applications to paradigmatic cases of platinum and gold drugs are highlighted.

中文翻译：

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核磁共振光谱研究金属药物在细胞中的命运。

基于金属的药物可以调节各种生物过程，并表现出丰富多样的特性，促进它们在生物医学和化学生物学中的应用。在到达细胞内靶标的过程中，可以发生配体交换和氧化还原反应，从而使体内金属药物物种形成成为一项具有挑战性的任务。核磁共振波谱的进步使得从溶液研究转向活细胞研究成为可能，并阐明了金属药物的转运以及在生理环境中与大分子靶标的相互作用。反过来，金属配合物的电子特性和超分子化学可用于通过 NMR 表征药物递送纳米系统。细胞内核磁共振方法的最新发展特别强调了与金属相关的过程。