Glutathione is the major thiol-containing species in both prokaryotes and eukaryotes and plays a wide variety of roles, including detoxification of metals by sequestration, reduction, and efflux. ABC transporters such as MRP1 and MRP2 detoxify the cell from certain metals by exporting the cations as a metal-glutathione complex. The ability of the bacterial Atm1 protein to efflux metal-glutathione complexes appears to have evolved over time to become the ABCB7 transporter in mammals, located in the inner mitochondrial membrane. No longer needed for the role of cellular detoxification, ABCB7 appears to be used to transport glutathione-coordinated iron-sulfur clusters from mitochondria to the cytosol.

中文翻译：

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谷胱甘肽配位的金属配合物作为细胞转运蛋白的底物。

谷胱甘肽是原核生物和真核生物中主要的含硫醇物种，并具有多种作用，包括通过螯合，还原和外排使金属解毒。ABC转运蛋白（例如MRP1和MRP2）通过将阳离子作为金属-谷胱甘肽复合物输出而使细胞从某些金属中解毒。细菌Atm1蛋白流出金属-谷胱甘肽复合物的能力似乎已经随着时间的流逝而发展成为位于线粒体内膜的哺乳动物中的ABCB7转运蛋白。不再需要细胞排毒的作用，ABCB7似乎已用于将谷胱甘肽配位的铁硫簇从线粒体运输到胞质溶胶。