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Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor.
Cell Research ( IF 44.1 ) Pub Date : 2021-05-06 , DOI: 10.1038/s41422-021-00507-8
Honghui Zhang 1, 2, 3, 4 , Tailai Chen 5, 6 , Keliang Wu 1, 2, 3, 4 , Zhenzhen Hou 1, 2, 3, 4 , Shigang Zhao 1, 2, 3, 4 , Chuanxin Zhang 1, 2, 3, 4 , Yuan Gao 1, 2, 3, 4 , Ming Gao 1, 2, 3, 4 , Zi-Jiang Chen 1, 2, 3, 4, 5, 6 , Han Zhao 1, 2, 3, 4
Affiliation  



中文翻译:

CHK1的主要突变导致核融合失败和合子停滞,可以通过CHK1抑制剂挽救。

更新日期:2021-05-06
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