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Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria
Annual Review of Phytopathology ( IF 9.1 ) Pub Date : 2021-08-25 , DOI: 10.1146/annurev-phyto-020620-095740
Janak Raj Joshi 1, 2 , Netaly Khazanov 3 , Amy Charkowski 4 , Adi Faigenboim 1 , Hanoch Senderowitz 3 , Iris Yedidia 1
Affiliation  

In the battle between bacteria and plants, bacteria often use a population density–dependent regulatory system known as quorum sensing (QS) to coordinate virulence gene expression. In response, plants use innate and induced defense mechanisms that include low-molecular-weight compounds, some of which serve as antivirulence agents by interfering with the QS machinery. The best-characterized QS system is driven by the autoinducer N-acyl-homoserine lactone (AHL), which is produced by AHL synthases (LuxI homologs) and perceived by response regulators (LuxR homologs). Several plant compounds have been shown to directly inhibit LuxI or LuxR. Gaining atomic-level insight into their mode of action and how they interfere with QS enzymes supports the identification and design of novel QS inhibitors.Such information can be gained by combining experimental work with molecular modeling and docking simulations. The summary of these findings shows that plant-derived compounds act as interkingdom cues and that these allomones specifically target bacterial communication systems.

中文翻译:


界际信号干扰:植物源性小分子对植物病原菌群体感应的影响

在细菌和植物之间的战斗中,细菌通常使用一种称为群体感应 (QS) 的种群密度依赖性调节系统来协调毒力基因表达。作为回应,植物使用先天和诱导防御机制,包括低分子量化合物,其中一些通过干扰 QS 机制作为抗毒剂。最佳表征的 QS 系统由自诱导器N驱动-酰基高丝氨酸内酯 (AHL),由 AHL 合酶(LuxI 同系物)产生并由反应调节剂(LuxR 同系物)感知。几种植物化合物已被证明可以直接抑制 LuxI 或 LuxR。获得对它们的作用模式以及它们如何干扰 QS 酶的原子级洞察力支持新型 QS 抑制剂的识别和设计。可以通过将实验工作与分子建模和对接模拟相结合来获得此类信息。这些发现的总结表明,植物来源的化合物充当界间线索,并且这些异素专门针对细菌通讯系统。

更新日期:2021-08-26
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