Meiotic drive systems are associated with low-frequency chromosomal inversions. These are expected to accumulate deleterious mutations due to reduced recombination and low effective population size. We test this prediction using the 'sex-ratio' (SR) meiotic drive system of the Malaysian stalk-eyed fly Teleopsis dalmanni. SR is associated with a large inversion (or inversions) on the X chromosome. In particular, we study eyespan in males carrying the SR chromosome, as this trait is a highly exaggerated, sexually dimorphic trait, known to have heightened condition-dependent expression. Larvae were raised in low and high larval food stress environments. SR males showed reduced eyespan under the low and high stress treatments, but there was no evidence of a condition-dependent decrease in eyespan under high stress. Similar but more complex patterns were observed for female eyespan, with evidence of additivity under low stress and heterosis under high stress. These results do not support the hypothesis that reduced sexual ornament size in meiotic drive males is due to a condition-dependent response to the putative increase in mutation load. Instead, reduced eyespan likely reflects compensatory resource allocation to different traits in response to drive-mediated destruction of sperm.

中文翻译：

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减数分裂驱动不会导致茎眼果蝇的性装饰的条件依赖性减少。

减数分裂驱动系统与低频染色体倒位有关。由于重组减少和有效种群规模低，预计这些会积累有害突变。我们使用马来西亚茎眼蝇 Teleopsis dalmanni 的“性别比”（SR）减数分裂驱动系统来测试这一预测。SR 与 X 染色体上的大倒位（或倒位）有关。特别是，我们研究了携带 SR 染色体的男性的眼宽，因为这种特征是一种高度夸大的两性异形特征，已知具有增强的条件依赖性表达。幼虫在低和高幼虫食物压力环境中饲养。SR 雄性在低压力和高压力处理下显示出眼展减少，但没有证据表明在高压力下眼展因条件而异。在雌性眼距中观察到类似但更复杂的模式，有证据表明低压力下的可加性和高压力下的杂种优势。这些结果不支持减数分裂驱动雄性的性装饰尺寸减小是由于对突变负荷假定增加的条件依赖性反应的假设。相反，缩短的眼距可能反映了对不同性状的补偿性资源分配，以响应驱动介导的精子破坏。