Obesity represents a well-known risk factor for renal cell carcinoma development. Several studies evaluated the relationship between obesity and outcome in patients with non-metastatic and metastatic renal cell carcinoma using different parameters such as body mass index, visceral fat area and subcutaneous fat area. These studies suggest that obesity is associated with a better prognosis in renal cell carcinoma patients. This phenomenon called obesity paradox was found in other diseases in which obesity represents an established risk factor such as heart failure, diabetes, atrial fibrillation, hypertension and coronary heart disease. The purpose of this review is to analyse the mechanisms by which obesity increases the risk of renal cell carcinoma development, to describe evidence available to date about the link obesity-outcome and to evaluate the mechanisms to explain this apparently paradoxical relationship.

中文翻译：

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肾细胞癌（RCC）：脂肪越好？肥胖在RCC中的作用综述。

肥胖是肾细胞癌发展的众所周知的危险因素。多项研究使用体重指数，内脏脂肪区和皮下脂肪区等不同参数评估了非转移性和转移性肾细胞癌患者肥胖与预后之间的关系。这些研究表明，肥胖与肾细胞癌患者预后更好有关。这种现象被称为“肥胖悖论”，在其他疾病中，肥胖是一种确定的危险因素，例如心力衰竭，糖尿病，心房颤动，高血压和冠心病。这篇综述的目的是分析肥胖增加肾脏细胞癌发展风险的机制，