BACKGROUND Pregnancy associated breast cancer is a rare disease. It presents a unique entity of breast cancer with aggressive phenotype. The main aim was to evaluate how the international guidelines were followed in daily practice. PATIENTS AND METHODS Data concerning patients' and tumours' characteristics, management, delivery and maternal outcome were recorded from institutional electronic database. In this paper a case series of pregnant breast cancer patients treated at single tertiary institution between 2007 and 2019 are presented and the key recommendations on managing such patients are summarized. RESULTS Fourteen patients met the search criteria. The majority of tumours were high grade, triple negative or HER2 positive, two patients were de novo metastatic. Treatment plan was made for each patient by multidisciplinary team. Eight patients were treated with systemic chemotherapy with no excess toxicity or severe maternal/fetal adverse effects. In all but two patients, delivery was on term and without major complications. Only one event, which was not in whole accordance with international guidelines, was identified. It was the use of blue dye in one patient. CONCLUSIONS Women with pregnancy associated breast cancer should be managed like non-pregnant breast cancer patients and should expect a similar outcome, without causing harm to the unborn child. To achieve a good outcome in pregnancy associated breast cancer, a multidisciplinary approach is mandatory.

中文翻译：

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妊娠期乳腺癌：回顾性机构病例系列。

背景妊娠相关乳腺癌是一种罕见病。它呈现出具有侵袭性表型的独特乳腺癌实体。主要目的是评估在日常实践中如何遵循国际准则。患者和方法 从机构电子数据库记录有关患者和肿瘤特征、管理、分娩和母体结果的数据。本文介绍了 2007 年至 2019 年间在单一三级机构接受治疗的妊娠乳腺癌患者的病例系列，并总结了管理此类患者的主要建议。结果 14 名患者符合搜索标准。大多数肿瘤为高级别、三阴性或 HER2 阳性，两名患者为新发转移。多学科团队为每位患者制定治疗计划。八名患者接受了全身化疗，没有过度毒性或严重的母体/胎儿不良反应。除两名患者外，所有患者均按期分娩，没有出现严重并发症。仅确定了一个不完全符合国际准则的事件。这是在一名患者身上使用蓝色染料。结论 患有妊娠相关乳腺癌的女性应该像未妊娠的乳腺癌患者一样进行管理，并且应该期望得到类似的结果，而不会对未出生的孩子造成伤害。为了在妊娠相关乳腺癌中取得良好的结果，必须采用多学科方法。这不完全符合国际准则，被确定。这是在一名患者身上使用蓝色染料。结论 患有妊娠相关乳腺癌的女性应该像未妊娠的乳腺癌患者一样进行管理，并且应该期望得到类似的结果，而不会对未出生的孩子造成伤害。为了在妊娠相关乳腺癌中取得良好的结果，必须采用多学科方法。这不完全符合国际准则，被确定。这是在一名患者身上使用蓝色染料。结论 患有妊娠相关乳腺癌的女性应该像未妊娠的乳腺癌患者一样进行管理，并且应该期望得到类似的结果，而不会对未出生的孩子造成伤害。为了在妊娠相关乳腺癌中取得良好的结果，必须采用多学科方法。