BACKGROUND Pregnancy associated breast cancer is a rare disease. It presents a unique entity of breast cancer with aggressive phenotype. The main aim was to evaluate how the international guidelines were followed in daily practice. PATIENTS AND METHODS Data concerning patients' and tumours' characteristics, management, delivery and maternal outcome were recorded from institutional electronic database. In this paper a case series of pregnant breast cancer patients treated at single tertiary institution between 2007 and 2019 are presented and the key recommendations on managing such patients are summarized. RESULTS Fourteen patients met the search criteria. The majority of tumours were high grade, triple negative or HER2 positive, two patients were de novo metastatic. Treatment plan was made for each patient by multidisciplinary team. Eight patients were treated with systemic chemotherapy with no excess toxicity or severe maternal/fetal adverse effects. In all but two patients, delivery was on term and without major complications. Only one event, which was not in whole accordance with international guidelines, was identified. It was the use of blue dye in one patient. CONCLUSIONS Women with pregnancy associated breast cancer should be managed like non-pregnant breast cancer patients and should expect a similar outcome, without causing harm to the unborn child. To achieve a good outcome in pregnancy associated breast cancer, a multidisciplinary approach is mandatory.

中文翻译：

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怀孕期间的乳腺癌：回顾性机构病例系列。

背景技术与妊娠相关的乳腺癌是一种罕见的疾病。它呈现出具有侵略性表型的乳腺癌的独特实体。主要目的是评估日常实践中如何遵循国际准则。患者和方法从机构电子数据库中记录有关患者和肿瘤特征，治疗，分娩和母亲结局的数据。本文介绍了2007年至2019年在一家大专院校接受治疗的孕妇乳腺癌患者的病例系列，并总结了处理此类患者的关键建议。结果14名患者符合搜索标准。多数肿瘤为高级别，三重阴性或HER2阳性，两名患者为从头转移。多学科团队为每位患者制定了治疗计划。八名患者接受了全身化学疗法治疗，无过度毒性或严重的母/胎儿不良反应。除两名患者外，其余患者均分娩，无严重并发症。仅发现了一件完全不符合国际准则的事件。一名患者使用了蓝色染料。结论妊娠相关乳腺癌的妇女应像未怀孕的乳腺癌患者一样进行治疗，并应预期有类似的结果，而不会对未出生的婴儿造成伤害。为了在妊娠相关的乳腺癌中取得良好的结果，必须采取多学科的方法。确定了不完全符合国际准则的问题。一名患者使用了蓝色染料。结论妊娠相关乳腺癌的妇女应像未怀孕的乳腺癌患者一样进行治疗，并应预期有类似的结果，而不会对未出生的婴儿造成伤害。为了在妊娠相关的乳腺癌中取得良好的结果，必须采取多学科的方法。确定了不完全符合国际准则的问题。一名患者使用了蓝色染料。结论妊娠相关乳腺癌的妇女应像未怀孕的乳腺癌患者一样进行治疗，并应预期有类似的结果，而不会对未出生的婴儿造成伤害。为了在妊娠相关的乳腺癌中取得良好的结果，必须采取多学科的方法。