Enzymes are very important for biological processes in a living being, performing similar or multiple tasks in and out of cells, tissues and other organisms at a particular location. The abnormal activity of particular enzyme usually caused serious diseases such as Alzheimer's disease, Parkinson's disease, cancers, diabetes, cardiovascular diseases, arthritis etc. Hence, nondestructive and real-time visualization for certain enzyme is very important for understanding the biological issues, as well as the drug administration and drug metabolism. Fluorescent cellular probe-based enzyme detectionin vitroandin vivohas become broad interest for human disease diagnostics and therapeutics. This review highlights the recent findings and designs of highly sensitive and selective fluorescent cellular probes targeting enzymes for quantitative analysis and bioimaging.

中文翻译：

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综述靶向酶的荧光探针的最新进展。

酶对于生物的生物过程非常重要，它可以在特定位置进出细胞，组织和其他生物，执行类似或多种任务。特定酶的异常活性通常会引起严重的疾病，例如阿尔茨海默氏病，帕金森氏病，癌症，糖尿病，心血管疾病，关节炎等。因此，某些酶的无损实时可视化对于理解生物学问题也非常重要。作为药物管理和药物代谢。体外和体内基于荧光细胞探针的酶检测已成为人类疾病诊断和治疗的广泛兴趣。