BACKGROUND Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) - a Th2-related cytokine - increase in various atopic diseases. It has been shown that vitamin D affects Treg cells and immune responses. Zinc as an essential trace element for cell-cell interactions, cellular differentiation, and proliferation. However, the effect of these markers on infantile AD and disease severity are mostly unknown. OBJECTIVE The aim of this study was to investigate the relationship between TARC, vitamin D, zinc levels, and the disease severity in infants with AD. METHOD AD patients (n = 160) with age and sex that matched healthy controls (n = 79) were included in the study. The diagnosis of AD was made based on the Hanifin-Rajka criteria. The objective SCORAD index was used for the assessment of disease severity. RESULTS A total of 160 patients (male 71.9%) with AD were included in the study. The median age of onset of symptoms was 2 (1.0-3.5) months. The lesions initially started on face 76.9%, neck 6.9%, extremities 7.5%, and body 8.8%. Nearly 40% of the patients were found to be atopic. Food allergy was found in 39.4%. The median of objective SCORAD index was 27.5 (17.5-40) in the study group. The TARC levels of AD patients were higher than control group [1803 pg/ml (1006- 3123) vs 709 pg/ml (504-1147), p < 0.001] There was a significant correlation between objective SCORAD scores and TARC values in subjects with AD (r = 0.363, p < 0.001). As the severity of AD increased, vitamin D levels decreased (p for trend 0.015) and TARC values increased (p for trend < 0.001). Serum zinc levels did not change with the severity of the disease. The presence of atopy did not have an influence on serum TARC, zinc, and vitamin D levels. CONCLUSION In infants with AD, disease severity is positively related with TARC levels; and inversely proportional to vitamin D levels. TARC levels differ between patients and healthy controls. The presence of atopy has not been shown to affect these markers. © 2021 Codon Publications. Published by Codon Publications.

中文翻译：

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婴儿特应性皮炎：血清维生素 D、锌和 TARC 水平及其与疾病表型和严重程度的关系。

背景 迄今为止，已经研究了影响特应性皮炎 (AD) 临床过程的几种标志物。胸腺和活化调节趋化因子 (TARC) - 一种 Th2 相关细胞因子 - 在各种特应性疾病中增加。已经表明维生素 D 会影响 Treg 细胞和免疫反应。锌是细胞间相互作用、细胞分化和增殖的必需微量元素。然而，这些标志物对婴儿 AD 和疾病严重程度的影响大多是未知的。目的 本研究的目的是调查 AD 婴儿的 TARC、维生素 D、锌水平与疾病严重程度之间的关系。方法 年龄和性别与健康对照（n = 79）相匹配的 AD 患者（n = 160）被纳入研究。AD的诊断基于Hanifin-Rajka标准。客观 SCORAD 指数用于评估疾病严重程度。结果 共有 160 名 AD 患者（男性 71.9%）被纳入研究。出现症状的中位年龄为 2 (1.0-3.5) 个月。病变最初开始于面部 76.9%、颈部 6.9%、四肢 7.5% 和身体 8.8%。近 40% 的患者被发现是特应性的。39.4% 的人发现食物过敏。研究组中客观 SCORAD 指数的中位数为 27.5 (17.5-40)。AD 患者的 TARC 水平高于对照组 [1803 pg/ml (1006-3123) vs 709 pg/ml (504-1147), p < 0.001] 受试者的客观 SCORAD 评分与 TARC 值之间存在显着相关性与 AD (r = 0.363, p < 0.001)。随着 AD 严重程度的增加，维生素 D 水平降低（趋势 p 为 0.015），TARC 值增加（趋势 p < 0.001）。血清锌水平不随疾病的严重程度而变化。特应性的存在对血清 TARC、锌和维生素 D 水平没有影响。结论在AD婴儿中，疾病严重程度与TARC水平呈正相关；并且与维生素 D 水平成反比。患者和健康对照之间的 TARC 水平不同。尚未证明特应性的存在会影响这些标志物。© 2021 密码子出版物。由密码子出版社出版。尚未证明特应性的存在会影响这些标志物。© 2021 密码子出版物。由密码子出版社出版。尚未证明特应性的存在会影响这些标志物。© 2021 密码子出版物。由密码子出版社出版。