The conserved lipase-like protein EDS1 transduces signals from pathogen-activated intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional defences and host cell death. In this pivotal NLR signalling role, EDS1 works as a heterodimer with each of its partners, SAG101 and PAD4. Different properties of EDS1-SAG101 and EDS1-PAD4 complexes and functional relationships to sensor and helper NLRs have emerged. EDS1-SAG101 dimers confer effector-triggered immunity mediated by intracellular TNL receptors. In contrast, EDS1-PAD4 dimers have a broader role promoting basal immune responses that can be initiated inside cells by TNL- or CNL-type NLRs, and at the cell surface by LRR-receptor proteins. Characterizing the essential elements of these two EDS1 modules will help to connect intracellular and surface receptor signalling networks in the plant immune system.

中文翻译：

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EDS1 信号：细胞内和表面受体免疫的联系。

保守的脂肪酶样蛋白 EDS1 将信号从病原体激活的细胞内核苷酸结合富含亮氨酸重复 (NLR) 受体转导到转录防御和宿主细胞死亡。在这个关键的 NLR 信号作用中，EDS1 作为异二聚体与其每个伙伴 SAG101 和 PAD4 一起工作。EDS1-SAG101 和 EDS1-PAD4 复合物的不同特性以及与传感器和辅助 NLR 的功能关系已经出现。EDS1-SAG101 二聚体赋予细胞内 TNL 受体介导的效应子触发免疫。相比之下，EDS1-PAD4 二聚体具有更广泛的促进基础免疫反应的作用，这些免疫反应可以在细胞内由 TNL 或 CNL 型 NLR 启动，并在细胞表面由 LRR 受体蛋白启动。