Nanosafety evaluation is paramount since it is necessary not only for human health protection and environmental integrity but also as a cornerstone for industrial and regulatory bodies. The current nanometallomics did not cover non-metallic nanomaterials, which is an important part of nanomaterials. In this critical review, the concept of nanometallomics was expanded to incorporate all nanomaterials. The impacts on metal(loid) and metallo-biomolecular homeostasis by nanomaterials will be focused upon in nanometallomics study. Besides, the impacts on elemental and biomolecular homeostasis by metallo-nanomaterials are also considered as the research subjects of nanometallomics. Based on the new concept of nanometallomics, comparative nanometallomics was proposed as a new tool for nanosafety evaluation, which is high throughput and will be precise considering the nature of machine learning techniques. The perspectives of nanometallomics like metallo-wide association study and non-target nanometallomics were put forward.

中文翻译：

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比较纳米金属组学作为纳米安全评估的新工具。

纳米安全评估至关重要，因为它不仅对人类健康保护和环境完整性必不可少，而且还是工业和监管机构的基石。目前的纳米金属组学并未涵盖非金属纳米材料，非金属纳米材料是纳米材料的重要组成部分。在这篇批判性评论中，纳米金属组学的概念被扩展到包含所有纳米材料。纳米材料对金属（类）和金属生物分子稳态的影响将是纳米金属组学研究的重点。此外，金属纳米材料对元素和生物分子稳态的影响也被认为是纳米金属组学的研究课题。基于纳米金属组学的新概念，比较纳米金属组学被提出作为纳米安全评价的新工具，考虑到机器学习技术的性质，这是高吞吐量并且将是精确的。提出了全金属关联研究和非靶点纳米金属组学等纳米金属组学的研究方向。