Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide, and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence OC risk. This review presents an overview of role of mitochondrial genetics in influencing OC development and discusses the contribution of mitochondrial proteome in OC development, progression and therapy. A role of mitochondrial genetics in racial disparity is also highlighted. In-depth understanding of role of mitochondria in OC will help develop strategies toward prevention and treatment and improving overall survival in women with OC.

中文翻译：

---

卵巢癌的线粒体景观：新兴见解。


卵巢癌（OC）被认为是全世界女性中最致命的癌症，但对其病因知之甚少。最近的研究表明，线粒体 DNA (mtDNA) 含量以及编码线粒体蛋白的线粒体 DNA 和核基因会影响 OC 风险。本综述概述了线粒体遗传学在影响 OC 发展中的作用，并讨论了线粒体蛋白质组在 OC 发展、进展和治疗中的贡献。线粒体遗传学在种族差异中的作用也得到了强调。深入了解线粒体在 OC 中的作用将有助于制定预防和治疗策略，并提高 OC 女性的总体生存率。