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How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model
Annual Review of Neuroscience ( IF 12.1 ) Pub Date : 2021-07-08 , DOI: 10.1146/annurev-neuro-102320-085825
Cristopher M Niell 1 , Massimo Scanziani 2
Affiliation  

The mouse, as a model organism to study the brain, gives us unprecedented experimental access to the mammalian cerebral cortex. By determining the cortex's cellular composition, revealing the interaction between its different components, and systematically perturbing these components, we are obtaining mechanistic insight into some of the most basic properties of cortical function. In this review, we describe recent advances in our understanding of how circuits of cortical neurons implement computations, as revealed by the study of mouse primary visual cortex. Further, we discuss how studying the mouse has broadened our understanding of the range of computations performed by visual cortex. Finally, we address how future approaches will fulfill the promise of the mouse in elucidating fundamental operations of cortex.

中文翻译:


皮层电路如何实现皮层计算:以小鼠视觉皮层为模型

小鼠作为研究大脑的模型生物,为我们提供了前所未有的哺乳动物大脑皮层实验途径。通过确定皮层的细胞组成,揭示其不同成分之间的相互作用,并系统地扰乱这些成分,我们获得了对皮层功能一些最基本特性的机制洞察。在这篇综述中,我们描述了我们对皮层神经元回路如何实现计算的理解的最新进展,正如小鼠初级视觉皮层研究所揭示的那样。此外,我们还讨论了对鼠标的研究如何拓宽了我们对视觉皮层执行的计算范围的理解。最后,我们讨论了未来的方法将如何实现鼠标在阐明皮层基本操作方面的承诺。

更新日期:2021-07-09
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