The Internet of Bio-NanoThings (IoBNTs) is a novel paradigm that derives from synthetic biology and advances in nanotechnology for controlling the embedded nanodevices in various medical applications. However, numerous studies have focused on communication efficiency among the nanodevices in a given network, the challenges such as the design and the development of the nanodevices, and the coordination of molecular communication within the wireless body area network (BAN), and the interface connection between the BAN and the Internet are yet to be addressed. Therefore, in this study, we present a framework analysis comprising of the compartmental model, for studying the effects and variances in drug concentration that occur inside intra-body nanonetworks through IoBNT, while taking into account the properties of target cells as well as the ligand-receptor binding mechanism. A performance analysis of the proposed framework for the forward link (i.e., from the Internet to the intra-body nanonetwork) and reverse link (i.e., from the intra-body nanonetwork to the Internet) is presented. The simulation results of the developed framework reveal its ability to enhance the delivery of therapeutic drugs to the target cell while minimizing the side effects in healthy cells.

中文翻译：

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基于生物纳米物联网的靶向给药高效框架分析。

生物纳米物联网 (IoBNTs) 是一种新的范式，它源自合成生物学和纳米技术的进步，用于控制各种医疗应用中的嵌入式纳米设备。然而，许多研究都集中在给定网络中纳米器件之间的通信效率、纳米器件的设计和开发、无线体域网 (BAN) 内分子通信的协调以及接口连接等挑战。 BAN 和 Internet 之间的问题尚未得到解决。因此，在本研究中，我们提出了一个由隔室模型组成的框架分析，用于研究通过 IoBNT 发生在体内纳米网络内的药物浓度的影响和变化，同时考虑到靶细胞的特性以及配体-受体结合机制。提出了前向链路（即从互联网到体内纳米网络）和反向链路（即从体内纳米网络到互联网）框架的性能分析。所开发框架的模拟结果显示其能够增强治疗药物向靶细胞的递送，同时最大限度地减少对健康细胞的副作用。