The Internet of Bio-NanoThings (IoBNTs) is a novel paradigm that derives from synthetic biology and advances in nanotechnology for controlling the embedded nanodevices in various medical applications. However, numerous studies have focused on communication efficiency among the nanodevices in a given network, the challenges such as the design and the development of the nanodevices, and the coordination of molecular communication within the wireless body area network (BAN), and the interface connection between the BAN and the Internet are yet to be addressed. Therefore, in this study, we present a framework analysis comprising of the compartmental model, for studying the effects and variances in drug concentration that occur inside intra-body nanonetworks through IoBNT, while taking into account the properties of target cells as well as the ligand-receptor binding mechanism. A performance analysis of the proposed framework for the forward link (i.e., from the Internet to the intra-body nanonetwork) and reverse link (i.e., from the intra-body nanonetwork to the Internet) is presented. The simulation results of the developed framework reveal its ability to enhance the delivery of therapeutic drugs to the target cell while minimizing the side effects in healthy cells.

中文翻译：

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基于Bio-NanoThings互联网的靶向药物输送的高效框架分析。

生物纳米物联网（IoBNT）是一种新颖的范例，它源于合成生物学和纳米技术的进步，用于控制各种医学应用中的嵌入式纳米设备。但是，大量研究集中在给定网络中纳米设备之间的通信效率，纳米设备的设计和开发，无线人体局域网（BAN）中分子通信的协调以及接口连接等挑战。 BAN和Internet之间的关系尚待解决。因此，在这项研究中，我们提出了一个包含隔室模型的框架分析，用于研究通过IoBNT在体内纳米网络内部发生的药物浓度的影响和方差，同时考虑到靶细胞的特性以及配体-受体结合机制。提出了对前向链路（即，从Internet到体内纳米网络）和反向链路（即，从体内的纳米网络到互联网）的建议框架的性能分析。所开发框架的模拟结果显示了其增强治疗药物向靶细胞的输送能力，同时最大程度地减少了健康细胞中的副作用的能力。