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RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics
Annual Review of Chemical and Biomolecular Engineering ( IF 7.6 ) Pub Date : 2021-06-07 , DOI: 10.1146/annurev-chembioeng-101420-014055
Walter Thavarajah 1, 2, 3 , Laura M Hertz 2, 4 , David Z Bushhouse 2, 4 , Chloé M Archuleta 1, 2, 3 , Julius B Lucks 1, 2, 3, 5
Affiliation  

RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges. Recent advances in the field of RNA engineering are bringing this to fruition, enabling the creation of RNA-based tools to combat some of the most urgent public health crises. Specifically, new diagnostics using engineered RNAs are able to detect both pathogens and chemicals while generating an easily detectable fluorescent signal as an indicator. New classes of vaccines and therapeutics are also using engineered RNAs to target a wide range of genetic and pathogenic diseases. Here, we discuss the recent breakthroughs in RNA engineering enabling these innovations and examine how advances in RNA design promise to accelerate the impact of engineered RNA systems.

中文翻译:


用于公共卫生的 RNA 工程:基于 RNA 的诊断和治疗的创新

RNA 对于细胞功能至关重要:从感知细胞内和细胞外信号到控制基因表达,RNA 介导了多种多样的分子过程。合成生物学的一个长期目标是开发 RNA 工程原理,这些原理可用于利用和重新编程这些 RNA 介导的过程,以设计生物系统来解决紧迫的全球挑战。RNA 工程领域的最新进展正在实现这一目标,从而能够创建基于 RNA 的工具来应对一些最紧迫的公共卫生危机。具体而言,使用工程 RNA 的新诊断能够检测病原体和化学物质,同时生成易于检测的荧光信号作为指示剂。新型疫苗和疗法也正在使用工程化的 RNA 来针对范围广泛的遗传和致病性疾病。在这里,我们讨论了最近在 RNA 工程中实现这些创新的突破,并研究了 RNA 设计的进步如何有望加速工程 RNA 系统的影响。

更新日期:2021-06-08
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