The nucleus is a highly structured organelle with many chromatin and protein compartments that partition the genome into regulatory domains. One such a compartment within the mammalian nucleus is the microenvironment underlying the nuclear envelope (NE) where intermediate filament proteins, lamins, act as a link between cytoskeletal and inner nuclear membrane (INM) proteins, chromatin binders and modifiers, and heterochromatin. These dynamic interactions regulate many cellular processes and, when they are perturbed, can lead to genome dysregulation and disease.

中文翻译：

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基因组的变化形状：核层中异染色质相互作用的动力学。

核是具有许多染色质和蛋白质区室的高度结构化的细胞器，该区室将基因组划分为调节域。哺乳动物核内的一个这样的区室是位于核被膜（NE）下方的微环境，其中中间的细丝蛋白，纤溶蛋白充当细胞骨架和内核膜（INM）蛋白，染色质结合剂和修饰剂以及异染色质之间的链接。这些动态相互作用调节许多细胞过程，当它们受到干扰时，可能导致基因组失调和疾病。