Biomedical Physics & Engineering Express ( IF 1.3 ) Pub Date : 2021-06-09 , DOI: 10.1088/2057-1976/abfaea Irfan Aditya Dharma 1, 2 , Daisuke Kawashima 1 , Marlin Ramadhan Baidillah 1 , Panji Nursetia Darma 1 , Masahiro Takei 1
In-vivo viscoelastic properties have been estimated in human subcutaneous adipose tissue (SAT) by integration of poroviscoelastic-mass transport model (pve-MTM) into wearable electrical impedance tomography (w-EIT) under the influence of external compressive pressure The pve-MTM predicts the ion concentration distribution by coupling the poroviscoelastic and mass transport model to describe the hydrodynamics, rheology, and transport phenomena inside SAT. The w-EIT measures the time-difference conductivity distribution in SAT resulted from the ion transport. Based on the integration, the two viscoelastic properties which are viscoelastic shear modulus of SAT and relaxation time of SAT are estimated by applying an iterative curve-fitting between the normalized average ion concentration distribution predicted from pve-MTM and the experimental normalized average ion concentration distribution derived from w-EIT. The in-vivo experiments were conducted by applying external compressive pressure on human calf boundary to induce interstitial fluid flow and ion movement in SAT. As a result, the value of was range from 4.9–6.3 kPa and the value of was range from 27.50–38.5 s with the value of average goodness-of-fit curve fitting R 2 >0.76. These values of and were compared to the human and animal tissue from the literature in order to verify this method. The results from pve-MTM provide evidence that and play a role in the predicted value of
中文翻译:
通过将多孔粘弹性质量传输模型 (pve-MTM) 整合到可穿戴电阻抗断层扫描 (w-EIT) 中,估计皮下脂肪组织的体内粘弹性
被检体内的粘弹性质已在人皮下脂肪组织(SAT)通过poroviscoelastic-质量传输模型(整合估计PVE -MTM)转换成可佩戴的电阻抗断层摄影(瓦特外部压缩压力的影响下-EIT)的PVE -MTM通过耦合多孔粘弹性和质量传输模型来预测离子浓度分布,以描述 SAT 内部的流体动力学、流变学和传输现象。该W¯¯ -EIT措施的时间差电导率分布在SAT源于离子传输。基于积分,SAT的粘弹性剪切模量这两个粘弹性特性SAT 的弛豫时间和弛豫时间是通过在从pve -MTM预测的归一化平均离子浓度分布和从w -EIT得出的实验归一化平均离子浓度分布之间应用迭代曲线拟合来估计的。所述的体内实验是通过施加外部压缩压力下进行人体小腿边界上,以诱导在SAT间质流体流动和离子移动。结果, 的值范围为 4.9-6.3 kPa, 的值范围为 27.50-38.5 s,拟合优度曲线拟合的平均值R 2 > 0.76。这些值和 与文献中的人和动物组织进行比较以验证该方法。pve -MTM的结果提供了证据,证明并在预测值中发挥作用