Current treatments for autoimmune diseases do not address the immune pathology underlying their initiation and progression and too often rely on non-specific immunosuppressive drugs for control of symptoms. Antigen-specific immunotherapy aims to induce tolerance selectively among the cells causing the disease while leaving the rest of the adaptive immune system capable of protecting against infectious diseases and cancers. Here we describe how novel approaches for antigen-specific immunotherapy are designed to manipulate antigen presentation and promote tolerance to specific self-antigens. This analysis points to liver antigen presenting cells, targeted by carrier particles, and steady-state dendritic cells, to which antigen-processing independent T-cell epitopes (apitopes) bind directly, as the principal targets for antigen-specific immunotherapy. Delivery of antigens to these cells holds great promise for effective control of this rapidly expanding group of diseases.

中文翻译：

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操纵抗原呈递用于自身免疫性疾病的抗原特异性免疫治疗。

目前对自身免疫性疾病的治疗并没有解决引发和进展的免疫病理学问题，并且过于依赖非特异性免疫抑制药物来控制症状。抗原特异性免疫疗法旨在选择性地诱导引起疾病的细胞之间的耐受性，同时使其余的适应性免疫系统能够预防传染病和癌症。在这里，我们描述了如何设计抗原特异性免疫疗法的新方法来操纵抗原呈递并促进对特定自身抗原的耐受性。该分析指出，由载体颗粒靶向的肝脏抗原呈递细胞和与抗原加工独立的 T 细胞表位 (apitopes) 直接结合的稳态树突状细胞作为抗原特异性免疫治疗的主要靶标。