Biofilms are important virulence factor in infections caused by microorganisms because of its complex structure, which provide resistance to conventional antimicrobials. Strategies involving the use of molecules capable of inhibiting their formation and also act synergistically with conventional drugs have been explored. Farnesol is a molecule present in essential oils and produced by Candida albicans as a quorum sensing component. This sesquiterpene presents inhibitory properties in the formation of microbial biofilms and synergism with antimicrobials used in clinical practice, and can be exploited even for eradication of biofilms formed by drug-resistant microorganisms. Despite this, farnesol has physical and chemical characteristics that can limit its use, such as high hydrophobicity and volatility. Therefore, nanotechnology may represent an option to improve the efficiency of this molecule in high complex environments such as biofilms. Nanostructured systems present important results in the improvement of treatment with different commercial drugs and molecules with therapeutic or preventive potential. The formation of nanoparticles offers advantages such as protection of the incorporated drugs against degradation, improved biodistribution and residence time in specific treatment sites. The combination of farnesol with nanotechnology may be promising for the development of more effective antibiofilm therapies, as it can improve its solubility, reduce volatility, and increase bioavailability. This review summarizes existing data about farnesol, its action on biofilms, and discusses its encapsulation in nanostructured systems. LAY SUMMARY Farnesol is a natural compound that inhibits the formation of biofilms from different microbial species. The encapsulation of this molecule in nanoparticles is a promising alternative for the development of more effective therapies against biofilms.

中文翻译：

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Farnesol：一种关于生物膜和纳米技术的方法。

由于其复杂的结构，生物膜是微生物引起的感染的重要毒力因子，对常规抗菌剂具有抵抗力。已经研究出涉及使用能够抑制其形成并且还与常规药物协同作用的分子的策略。法尼醇是存在于精油中的分子，由白色念珠菌作为群体感应成分生产。该倍半萜烯在微生物生物膜的形成中具有抑制特性，并且与临床实践中使用的抗菌剂具有协同作用，甚至可以用于消除由耐药微生物形成的生物膜。尽管如此，法尼醇具有会限制其使用的物理和化学特性，例如高疏水性和挥发性。所以，纳米技术可能是提高这种分子在生物膜等高复杂环境中效率的一种选择。纳米结构系统在改善使用具有治疗或预防潜力的不同商业药物和分子的治疗方面显示出重要的成果。纳米颗粒的形成提供了优点，例如保护掺入的药物免于降解，改善的生物分布和在特定治疗部位的停留时间。法尼醇与纳米技术的结合对于开发更有效的抗生物膜疗法可能是有希望的，因为它可以提高其溶解度，降低挥发性和增加生物利用度。这篇综述总结了有关法尼醇的现有数据及其在生物膜上的作用，并讨论了其在纳米结构系统中的包封。发明内容法尼醇是一种天然化合物，可抑制来自不同微生物物种的生物膜的形成。该分子在纳米颗粒中的包封是开发针对生物膜的更有效疗法的有前途的替代方法。