BACKGROUND Nowadays, moisturizers contain non-steroidal anti-inflammatory agents that help for treatment of atopic dermatitis (AD). Defensil® (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts, remain had a few studies for AD. OBJECTIVE To compare the effectiveness of moisturizer containing 3% Defensil®, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in childhood AD treatment. METHODS Thirty-eight patients with diagnosis of atopic dermatitis by UK working party's criteria were recruited in randomized, controlled, double-blinded 4-week study. The patients were received with twice-daily application of LDC cream on one side of the body and 5% urea cream on the opposite side. The clinical severity was assessed by modified scoring of atopic dermatitis (SCORAD). Median time to remission was analyzed by survival analysis. RESULTS Thirty-seven out of 38 patients accomplished the protocol. The clinical SCORAD significantly improved from baseline in both groups (p < 0.001) after 2 and 4 weeks. Furthermore, the LDC group significantly reduced severity of disease better than the 5% urea group (P = 0.043). The mean difference SCORAD scores were -13.83 (±1.83) and -13.04 (±3.22) respectively. Stratum corneum hydration (SCH) was enhanced from baseline in both groups (p < 0.001) but no statistically significant difference between both groups. Median time to remission had no statistically significant difference (P = 0.697). CONCLUSIONS The effectiveness of LDC cream is better than 5% urea cream for improving clinical atopic dermatitis. It was suggested that moisturizer containing LDC could be used for the treatment of mild-to-moderate childhood atopic dermatitis.

中文翻译：

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一种含有亚油酸、5% 右泛醇和神经酰胺的乳膏，用于治疗特应性皮炎。


背景技术如今，保湿霜含有非甾体类抗炎剂，有助于治疗特应性皮炎(AD)。 Defensil®（黑醋栗籽油、葵花籽油和气球藤）是一种从植物提取物中提取的新型抗炎药，目前仍有一些针对 AD 的研究。目的 比较含有 3% Defensil®、5% 右泛醇和神经酰胺 (LDC) 的保湿霜与 5% 尿素霜在儿童 AD 治疗中的效果。方法 招募了 38 名根据英国工作组标准诊断为特应性皮炎的患者进行为期 4 周的随机、对照、双盲研究。患者每天两次在身体一侧涂抹LDC乳膏，在另一侧涂抹5%尿素乳膏。通过改良特应性皮炎评分（SCORAD）评估临床严重程度。通过生存分析来分析中位缓解时间。结果 38 名患者中有 37 名完成了该方案。 2 周和 4 周后，两组的临床 SCORAD 均较基线显着改善 (p < 0.001)。此外，LDC 组比 5% 尿素组更能显着降低疾病的严重程度 (P = 0.043)。 SCORAD 评分的平均差值分别为-13.83 (±1.83) 和-13.04 (±3.22)。两组的角质层水合作用 (SCH) 均较基线有所增强 (p < 0.001)，但两组之间无统计学显着差异。中位缓解时间没有统计学上的显着差异（P = 0.697）。结论 LDC乳膏改善临床特应性皮炎的效果优于5%尿素乳膏。有人建议含有LDC的保湿霜可用于治疗轻至中度儿童特应性皮炎。