PURPOSE Data on an association between Helicobacter pylori (H. pylori) and nutritional status in children are conflicting. We designed a large-sampled prospective community-based study to examine the differences in average body indices among Polish teenagers depending on their H. pylori status. METHODS From September 2008 to June 2015, 3067 second junior high school students aged between 13 and 17 years (mean age: 14.5) from 11 randomly selected schools from Grudziadz, Poland, were recruited. For the cohort, 13C urea breath test for current H. pylori infection was performed and data on anthropometric measurements and sociodemographic characteristics were collected. Z scores of height for age (HAZ), weight for age (WAZ), and BMI for age (BMIZ) were calculated. RESULTS The H. pylori colonisation rate was 23.6% with no gender difference. Compared to noninfected, H. pylori infected had significantly lower mean WAZ (0.0085) and BMIZ scores (p = 0.0246). Univariate linear regression models showed that living in the old town district and consumption of tap water were negative predictors of HAZ, living in the old town district, using collective catering facilities, and H. pylori infection were negative predictors of WAZ, and using collective catering facilities and H. pylori infection were negative predictors of BMIZ. In the multiple regression analyses, living in the old town district (p = 0.0039), using collective catering facilities (p < 0.0001), and H. pylori infection (p = 0.0269) were confirmed to be independently associated with lower WAZ, whereas using collective catering facilities (p < 0.0001) and H. pylori infection (p = 0.0265) were confirmed to be independently associated also with lower BMIZ. CONCLUSION Our finding confirms the evidence on independent negative influence of H. pylori infection on nutritional status in Polish teenagers.

中文翻译：

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幽门螺杆菌感染对波兰青少年营养状况的影响。

目的 关于幽门螺杆菌 (H. pylori) 与儿童营养状况之间关联的数据相互矛盾。我们设计了一项基于社区的大样本前瞻性研究，以检查波兰青少年平均身体指数的差异，具体取决于他们的幽门螺杆菌状态。方法 2008 年 9 月至 2015 年 6 月，从波兰格鲁齐亚兹的 11 所随机抽取的学校中招募了 3067 名年龄在 13 至 17 岁之间（平均年龄：14.5 岁）的初中生。对于该队列，对当前幽门螺杆菌感染进行了 13C 尿素呼气试验，并收集了人体测量和社会人口学特征的数据。计算年龄别身高（HAZ）、年龄别体重（WAZ）和年龄别BMI（BMIZ）的Z分数。结果H. pylori定植率为23.6%，无性别差异。与未感染者相比，感染幽门螺杆菌的平均 WAZ (0.0085) 和 BMIZ 评分显着降低 (p = 0.0246)。单因素线性回归模型显示，居住在老城区和饮用自来水是HAZ的负预测因子，居住在老城区，使用集体餐饮设施，H. pylori感染是WAZ的负预测因子，使用集体餐饮设施和幽门螺杆菌感染是 BMIZ 的负预测因子。在多元回归分析中，证实居住在老城区 (p = 0.0039)、使用集体餐饮设施 (p < 0.0001) 和幽门螺杆菌感染 (p = 0.0269) 与较低的 WAZ 独立相关，而使用集体餐饮设施 (p < 0.0001) 和幽门螺杆菌感染 (p = 0. 0265）被证实与较低的 BMIZ 独立相关。结论 我们的发现证实了幽门螺杆菌感染对波兰青少年营养状况的独立负面影响的证据。