Purpose Data on an association between Helicobacter pylori (H. pylori) and nutritional status in children are conflicting. We designed a large-sampled prospective community-based study to examine the differences in average body indices among Polish teenagers depending on their H. pylori status. Methods From September 2008 to June 2015, 3067 second junior high school students aged between 13 and 17 years (mean age: 14.5) from 11 randomly selected schools from Grudziadz, Poland, were recruited. For the cohort, 13C urea breath test for current H. pylori infection was performed and data on anthropometric measurements and sociodemographic characteristics were collected. Z scores of height for age (HAZ), weight for age (WAZ), and BMI for age (BMIZ) were calculated. Results The H. pylori colonisation rate was 23.6% with no gender difference. Compared to noninfected, H. pylori infected had significantly lower mean WAZ (0.0085) and BMIZ scores (p = 0.0246). Univariate linear regression models showed that living in the old town district and consumption of tap water were negative predictors of HAZ, living in the old town district, using collective catering facilities, and H. pylori infection were negative predictors of WAZ, and using collective catering facilities and H. pylori infection were negative predictors of BMIZ. In the multiple regression analyses, living in the old town district (p = 0.0039), using collective catering facilities (p < 0.0001), and H. pylori infection (p = 0.0269) were confirmed to be independently associated with lower WAZ, whereas using collective catering facilities (p < 0.0001) and H. pylori infection (p = 0.0265) were confirmed to be independently associated also with lower BMIZ. Conclusion Our finding confirms the evidence on independent negative influence of H. pylori infection on nutritional status in Polish teenagers.

中文翻译：

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幽门螺杆菌感染对波兰青少年营养状况的影响。

目的关于幽门螺杆菌（H. pylori）与儿童营养状况之间关联的数据存在矛盾。我们设计了一项基于社区的前瞻性大样本研究，以检查波兰青少年中幽门螺杆菌状况的平均身体指数差异。方法2008年9月至2015年6月，从波兰Grudziadz随机选择的11所学校中招募了3067名年龄在13至17岁（平均年龄：14.5）之间的初中学生。对于该队列，对当前的幽门螺杆菌感染进行了13C尿素呼气试验，并收集了人体测量数据和社会人口统计学特征。计算了年龄的身高（HAZ），年龄的体重（WAZ）和年龄的BMI（BMIZ）的Z得分。结果幽门螺杆菌定植率为23.6％，无性别差异。与未感染的幽门螺杆菌相比，幽门螺杆菌感染的平均WAZ（0.0085）和BMIZ得分明显较低（p = 0.0246）。单变量线性回归模型显示，居住在旧城区和使用自来水是HAZ的阴性指标，居住在旧城区，使用集体饮食设施，而幽门螺杆菌感染是WAZ的阴性指标，并且使用集体饮食设施和幽门螺杆菌感染是BMIZ的阴性预测因子。在多元回归分析中，证实居住在旧城区（p = 0.0039），使用集体饮食设施（p <0.0001）和幽门螺杆菌感染（p = 0.0269）与较低的WAZ独立相关，而使用集体饮食设施（p <0.0001）和幽门螺杆菌感染（p = 0。0265）被确认也与较低的BMIZ独立相关。结论我们的发现证实了幽门螺杆菌感染对波兰青少年营养状况的独立负面影响的证据。