Elevated neuroticism may confer vulnerability to the depressogenic effects of stressful life events (SLEs). However, the mechanisms underlying this susceptibility remain poorly understood. Accumulating evidence suggests that stress-related disruptions in neural reward processing might undergird links between stress and depression. Using data from the Saint Louis Personality and Aging Network (SPAN) study and Duke Neurogenetics Study (DNS), we examined whether neuroticism moderates links between stressful life events (SLE) and depression as well as SLEs and ventral striatum (VS) response to reward. In the longitudinal SPAN sample (n = 971 older adults), SLEs prospectively predicted future depressive symptoms, especially among those reporting elevated neuroticism, even after accounting for prior depressive symptoms and previous SLE exposure (NxSLE interaction: p = .016, ΔR² = 0.003). Cross-sectional analyses of the DNS, a young adult college sample with neuroimaging data, replicated this interaction (n = 1,343: NxSLE interaction: p = .019, ΔR² = 0.003) and provided evidence that neuroticism moderates the association between SLEs and reward-related VS response (n = 1,195, NxSLE: p = .017, ΔR² = 0.0048). Blunted left VS response to reward was associated with a lifetime depression diagnosis, r = -0.07, p = .02, but not current depressive symptoms, r = -0.003, p = .93. These data suggest that neuroticism may promote vulnerability to stress-related depression and that sensitivity to stress-related reductions in VS response may be a potential neural mechanism underlying vulnerability to clinically significant depression. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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神经质和奖励相关的腹侧纹状体活动：探索与压力相关的抑郁症的脆弱性。

升高的神经质可能会导致易受压力生活事件 (SLE) 的抑郁影响。然而，这种易感性背后的机制仍然知之甚少。越来越多的证据表明，与压力相关的神经奖励处理中断可能是压力和抑郁之间联系的基础。使用来自圣路易斯人格和衰老网络 (SPAN) 研究和杜克神经遗传学研究 (DNS) 的数据，我们检查了神经质是否会调节压力性生活事件 (SLE) 和抑郁症以及 SLE 和腹侧纹状体 (VS) 对奖励的反应之间的联系. 在纵向 SPAN 样本（n = 971 名老年人）中，SLE 前瞻性地预测了未来的抑郁症状，特别是在那些报告神经质升高的人中，即使考虑了之前的抑郁症状和之前的 SLE 暴露（NxSLE 交互作用：p = .016，ΔR² = 0.003）。DNS 的横断面分析是一个具有神经影像数据的年轻成人大学样本，复制了这种相互作用（n = 1,343：NxSLE 相互作用：p = .019，ΔR² = 0.003）并提供证据表明神经质会调节 SLE 和奖励之间的关联-相关的 VS 响应（n = 1,195，NxSLE：p = .017，ΔR² = 0.0048）。左 VS 对奖励的反应迟钝与终生抑郁症诊断相关，r = -0.07，p = .02，但与当前的抑郁症状无关，r = -0.003，p = .93。这些数据表明，神经质可能会促进对与压力相关的抑郁症的易感性，并且对与压力相关的 VS 反应减少的敏感性可能是潜在的神经机制，可能是对临床显着抑郁症易感性的潜在神经机制。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。