Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients. Forced expression of ATOH8-V1 dramatically enhances, while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines. Moreover, ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC, which in turn enhances the metastasis of breast cancer. Altogether, our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis, suggesting that ATOH8-V1 is a potential therapeutic target for treatment of metastatic cancers.

中文翻译：

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ATOH8的新型同工型通过调节RhoC促进乳腺癌的转移。

转移是乳腺癌中与癌症相关的死亡率的主要原因。尽管在肿瘤转移领域已取得显着进展，但尚不清楚与肿瘤转移有关的确切分子机制。在这里，我们报道ATOH8-V1，一种新型的ATOH8亚型，在乳腺癌中高表达，是患者生存的阴性预后指标。ATOH8-V1的强制表达显着增强，而ATOH8-V1的沉默则降低乳腺癌细胞系的转移。此外，ATOH8-V1直接与RhoC启动子结合并刺激RhoC的表达，进而增强乳腺癌的转移。总而言之，我们的数据表明ATOH8-V1是一种新型的促转移因子，可增强癌症转移，