INTRODUCTION Compared with traditional cancer treatment methods, tumor-targeted immunotherapy can combine targeted therapy and immunotherapy with long-lasting responses to achieve synergistic therapy, which brings hope to the complete cure of cancer. AREAS COVERED This review summarizes the newest and most up-to-date advances in tumor-targeted immunotherapy, including tumor-associated macrophages (TAMs) targeted immunotherapy, regulatory T (Treg) cells targeted immunotherapy, tumor-associated fibroblasts (TAFs) targeted immunotherapy and immune checkpoints targeted immunotherapy. EXPERT OPINION Immunotherapy can restore anti-tumor immunity in the tumor microenvironment and produce a lasting immune surveillance effect. Smart multifunctional nano delivery system can effectively combine targeted therapy with immunotherapy, which has attracted extensive attention. With the deepening of research, more and more tumor-targeted immunotherapy enter into the clinical trial phases, especially antibodies and inhibitors. Tumor-targeted immunotherapy is a promising approach for conquering cancer and bringing hope for human health.

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肿瘤靶向免疫治疗的研究进展。

引言与传统的癌症治疗方法相比，肿瘤靶向免疫疗法可以将靶向疗法和免疫疗法结合起来并具有长效反应，以实现协同治疗，这为彻底治愈癌症带来了希望。涵盖的领域这项综述总结了肿瘤靶向免疫治疗的最新进展，包括肿瘤相关巨噬细胞（TAM）靶向免疫治疗，调节性T（Treg）细胞靶向免疫治疗，肿瘤相关成纤维细胞（TAFs）靶向免疫治疗。和免疫检查站针对性的免疫疗法。专家意见免疫疗法可以在肿瘤微环境中恢复抗肿瘤免疫力，并产生持久的免疫监视效果。智能多功能纳米递送系统可以有效地将靶向治疗与免疫治疗相结合，这引起了广泛的关注。随着研究的深入，越来越多的针对肿瘤的免疫疗法进入临床试验阶段，尤其是抗体和抑制剂。靶向肿瘤的免疫疗法是征服癌症并为人类健康带来希望的有前途的方法。