Curcumin has great potential in cancer treatment and prevention. However, free curcumin for anticancer effect is limited due to its low water solubility and instability. Delivery of free curcumin using biodegradable and biocompatible polymers, such as poly (lactic-co-glycolic acid) (PLGA), can improve these undesirable problems. In this study, a top-down fabrication method using PLGA was employed to deliver free curcumin, engineering size, shape, and surface properties. As a result, porous discoidal polymeric particles (DPPs) were produced in ammonium bicarbonate with a hydrodynamic diameter of 5 µm and a negatively charged surface. The loading amount of free curcumin in the porous DPPs was higher than non-porous DPPs. In vitro drug release study showed that curcumin release from porous DPPs was 1.4-fold higher than non-porous ones. The confocal microscopy and flow cytometry results demonstrated that porous DPPs decrease phagocytosis by macrophages than non-porous ones. This study suggests that porous DPPs have significant advantages for effective drug delivery of curcumin, minimizing phagocytosis.

中文翻译：

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多孔盘状聚合物颗粒可有效输送药物，最大限度地减少吞噬作用。


姜黄素在癌症治疗和预防方面具有巨大潜力。然而，游离姜黄素的抗癌作用由于其低水溶性和不稳定性而受到限制。使用可生物降解和生物相容性聚合物（例如聚乳酸乙醇酸共聚物（PLGA））输送游离姜黄素可以改善这些不良问题。在本研究中，采用使用 PLGA 的自上而下的制造方法来提供游离姜黄素、工程尺寸、形状和表面特性。结果，在碳酸氢铵中产生了流体动力学直径为 5 µm 且表面带负电的多孔盘状聚合物颗粒 (DPP)。多孔DPP中游离姜黄素的负载量高于非多孔DPP。体外药物释放研究表明，多孔 DPP 中姜黄素的释放量是非多孔 DPP 的 1.4 倍。共聚焦显微镜和流式细胞术结果表明，多孔 DPP 比无孔 DPP 减少了巨噬细胞的吞噬作用。这项研究表明，多孔 DPP 在姜黄素的有效药物递送、最大限度地减少吞噬作用方面具有显着优势。