The auditory mismatch negativity, a component of the event-related potential elicited by an unexpected stimulus in a sequence of acoustic stimuli, provides an objective measure of the accuracy of the echoic information processing of the human brain in vivo. Auditory mismatch negativity is also a useful probe of cortical glutamatergic N-methyl-d-aspartate receptor activity and disturbance. Notably, auditory mismatch negativity is consistently impaired in schizophrenia. Because of the wide spectrum extending from bipolar affective illness and schizoaffective psychosis to typical schizophrenia, we examined the literature on auditory mismatch negativity in bipolar disorder with the aim to find any neurophysiological dysfunction concerning pre-attentive information processing shared by these clinical conditions. This focused review includes 26 original articles published in peer-reviewed journals and indexed in the National Institutes of Health National Library of Medicine (PubMed) search system. Overall, evidence is consistent with the finding that auditory mismatch negativity is impaired in bipolar disorder with psychotic features, even though to a lesser extent than in schizophrenia. It must be acknowledged that, in a few twin and family studies, mismatch negativity abnormalities were not specifically associated with bipolar disorder. In conclusion, auditory mismatch negativity research supports the involvement of the N-methyl-d-aspartate system in the pathophysiology of bipolar disorder, as previously assessed for schizophrenia, thus creating an intriguing trait d'union between these two mental illnesses and stimulating the development of novel therapeutic agents. With additional replication and validation, auditory mismatch negativity may be further considered as a correlate of a common psychopathology of schizophrenia and bipolar spectrum illnesses.

中文翻译：

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双相情感障碍的听觉失配阴性：一项重点综述。

听觉失配否定性是由一系列声刺激中的意外刺激引起的与事件相关的电位的组成部分，它提供了客观的方法来衡量人脑在体内的回声信息处理的准确性。听觉失配负性也是皮层谷氨酸能N-甲基-d-天冬氨酸受体活性和紊乱的有用探针。值得注意的是，精神分裂症的听觉失配阴性一直受到损害。由于从双相情感性疾病和分裂情感性精神病到典型的精神分裂症的范围很广，我们研究了双相情感障碍听觉失配阴性的文献，目的是寻找与这些临床情况共享的有关注意前信息处理的任何神经生理功能障碍。这篇重点综述包括26篇原创文章，这些文章发表在同行评议的期刊上，并在美国国立卫生研究院国家医学图书馆（PubMed）的搜索系统中进行了索引。总体而言，证据与具有精神病特征的双相情感障碍听觉失配阴性受到损害的发现是一致的，尽管程度要比精神分裂症小。必须承认，在一些双胞胎和家族研究中，失配负性异常与双相情感障碍没有特定关系。总之，听觉失配负性研究支持N-甲基-d-天冬氨酸系统参与双相情感障碍的病理生理学，如先前对精神分裂症的评估，从而创造了一个有趣的特征d'。这两种精神疾病之间的结合并刺激了新型治疗剂的发展。通过额外的复制和验证，听觉失配阴性可进一步被认为是精神分裂症和双相谱疾病的常见精神病理学的相关因素。