BACKGROUND Disclosure of one's sexual orientation as a sexual-minority (SM) person (i.e., being "out") may affect HIV-related health outcomes. This longitudinal study examined whether race/ethnicity moderated effects of outness on the plasma kynurenine/tryptophan (KT) ratio, a marker of dysregulated serotonin metabolism due to immune activation that predicts clinical HIV progression. METHODS Participants were African American, Hispanic/Latino, and non-Hispanic White, methamphetamine-using SM men living with HIV (N = 97) who completed self-report scales of outness and SM stress at baseline for a randomized controlled trial of a positive affect intervention. Linear mixed modeling was used to test whether race/ethnicity and experimental condition moderated the association of baseline outness with the KT ratio at baseline, 6, 12, and 15 months controlling for SM stress, sociodemographics, HIV disease markers, and recent stimulant use. RESULTS The interactions of outness by race/ethnicity and outness by experimental condition on the KT ratio were significant. Greater outness predicted a lower KT ratio over time in non-Hispanic White SM men, but not among SM men of color (MOC). Greater outness predicted a lower KT ratio over time for SM men in the control, but not among those in the intervention arm. CONCLUSION Being more out may be protective for non-Hispanic White SM men, but not for their SM MOC peers. Outness mattered for participants who did not receive the positive affect intervention. Findings underscore the potentially different contexts and consequences of outness depending on SM men's race/ethnicity and whether they received a positive affect intervention. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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使用兴奋剂的性少数感染艾滋病毒的男性中的交叉少数地位和色氨酸降解。

背景技术公开一个人作为性少数(SM)人士的性取向(即“出局”)可能会影响与HIV相关的健康结果。这项纵向研究检验了种族/族裔是否调节了外在对血浆犬尿氨酸/色氨酸（KT）比率的影响，这是由于免疫激活导致的血清素代谢失调的标志物，可预测临床艾滋病毒的进展。方法 参与者是非洲裔美国人、西班牙裔/拉丁裔和非西班牙裔白人、使用甲基苯丙胺的 HIV 感染者 SM 男性 (N = 97)，他们在基线时完成了自我报告的外在和 SM 压力量表，以进行一项阳性的随机对照试验。影响干预。使用线性混合模型来测试种族/族裔和实验条件是否调节基线外在性与基线、6、12 和 15 个月时的 KT 比率之间的关联，并控制 SM 压力、社会人口统计学、HIV 疾病标志物和近期兴奋剂使用。结果 种族/民族的外在性和实验条件的外在性对 KT 比率的影响显着。随着时间的推移，非西班牙裔白人 SM 男性的外貌程度越高，KT 比率就越低，但 SM 有色人种男性 (MOC) 则不然。随着时间的推移，对照组中的 SM 男性的 KT 比率越大，但干预组中的男性则不然。结论 更加外出可能对非西班牙裔白人 SM 男性有保护作用，但对他们的 SM MOC 同龄人则不然。对于没有接受积极情感干预的参与者来说，外在很重要。研究结果强调了外在的潜在不同背景和后果，具体取决于 SM 男性的种族/民族以及他们是否接受了积极的情感干预。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。