The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca²⁺ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca²⁺-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

分泌囊泡与质膜的融合取决于 v-SNARE (VAMP2/synaptobrevin2) 和 t-SNARE (SNAP25/syntaxin1) 组装到 SNARE 复合物中。囊泡经过几个上游步骤，称为对接和启动，以获得融合能力。囊泡蛋白 synaptotagmin-1 (Syt-1) 是几个中枢神经系统神经元和神经内分泌细胞融合的主要 Ca ^{2+传感器，也是分泌颗粒对接复合物的一部分。}Syt-1与质膜上的synaxin1、SNAP-25等受体复合物结合，促进分泌囊泡对接，Ca ²⁺流入后，促进囊泡融合。本综述评估了 Syt-1 蛋白在分泌囊泡对接、启动和融合中的作用。