Limited detection power has been a bottleneck for subject-specific functional MRI (fMRI) studies, however the higher signal-to-noise ratio afforded by ultra-high magnetic fields (≥ 7 Tesla) provides levels of sensitivity and resolution needed to study individual subjects. What may be surprising is that higher imaging resolution may provide both higher specificity and sensitivity due to reductions in partial volume effects and reduced physiological noise. However, challenges remain to ensure high data quality and to reduce variability in ultra-high field fMRI. We discuss session-specific biases including those caused by factors related to instrumentation, anatomy, and physiology-which can translate into variability across sessions-and how to minimize these to help ultra-high field fMRI reach its full potential for individual-focused studies.

中文翻译：

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7 Tesla 的高分辨率 fMRI：以个人为中心的 fMRI 研究的挑战、承诺和最新发展。

有限的检测能力一直是特定对象功能 MRI (fMRI) 研究的瓶颈，但超高磁场 (≥ 7 特斯拉) 提供的更高信噪比提供了研究个体对象所需的灵敏度和分辨率水平. 令人惊讶的是，由于部分体积效应的降低和生理噪声的降低，更高的成像分辨率可以提供更高的特异性和灵敏度。然而，确保高数据质量和减少超高场 fMRI 的可变性仍然存在挑战。我们讨论了特定于会话的偏差，包括由与仪器、解剖学和生理学相关的因素引起的偏差——这些偏差可以转化为不同会话的变异性——以及如何将这些偏差最小化，以帮助超高场 fMRI 充分发挥其以个人为中心的研究的潜力。