INTRODUCTION Smoking increases the risk of arrhythmia. QT dispersion (QTd) is an important indicator for the determination of ventricular arrhythmia. In this study, we aimed to determine the arrhythmia risk by evaluating QTd in smokers and to assess the relationship between the level of nicotine addiction and carbon monoxide (CO) level in the expiratory air. METHODS This study was designed as a single-center, cross-sectional study. Among the chronic smokers referred to the Smoking Cessation Clinic of a tertiary hospital between October 2019 and January 2020, all those who had no risk factors for cardiac arrhythmias, except smoking, were included in the study. Sociodemographic data and smoking characteristics of the participants were collected and exhaled CO levels were measured. QT intervals were measured in all leads by using a 12-lead standard electrocardiogram (ECG), and heart rate corrected QT (QTc) intervals, QT dispersion (QTd), and corrected QT dispersion (QTcd) were calculated. RESULTS The mean age of the 250 patients was 37.2±9.3 years and the majority of patients (65%) were male. The mean amount of smoking was 25.74±16.03 packs/year and the mean value of CO was 12.36±7.06 ppm. The mean QTd was 23.83±13.12 ms, and the mean QTcd was 26.63±15.02 ms. A statistically significant relationship was found between QTd and QTcd and level of addiction, consumption of sticks/day and packs/year, and exhaled CO values (all p<0.001). CONCLUSIONS It was found that as the level of addiction, cigarette use amount, exhaled CO levels, and BMI increased in smokers, QT dispersion and arrhythmia risk increased.

中文翻译：

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评估吸烟者的成瘾水平和呼出一氧化碳水平与QT离散度之间的关系。

简介吸烟会增加心律失常的风险。QT离散度（QTd）是确定室性心律不齐的重要指标。在这项研究中，我们旨在通过评估吸烟者的QTd来确定心律失常的风险，并评估呼气中尼古丁成瘾水平与一氧化碳（CO）水平之间的关系。方法本研究被设计为单中心，横断面研究。在2019年10月至2020年1月之间转诊至三级医院戒烟诊所的慢性吸烟者中，除吸烟外，所有无心律失常危险因素的人都纳入了研究。收集参与者的社会人口统计学数据和吸烟特征，并测量呼出一氧化碳水平。使用12导联标准心电图（ECG）测量所有导联的QT间隔，并计算心率校正的QT（QTc）间隔，QT离散度（QTd）和校正的QT离散度（QTcd）。结果250例患者的平均年龄为37.2±9.3岁，大多数患者（65％）为男性。每年的平均吸烟量为25.74±16.03包/年，CO的平均值为12.36±7.06 ppm。平均QTd为23.83±13.12 ms，平均QTcd为26.63±15.02 ms。在QTd和QTcd与成瘾水平，棍棒/天和包/年的消耗量以及呼出的CO值之间发现了统计学上显着的关系（所有p <0.001）。结论发现，随着吸烟者的成瘾水平，吸烟量，呼出的CO水平和BMI的增加，QT离散度和心律失常的风险增加。