Recent experiments have demonstrated a nucleus where chromatin is molded into stable, interwoven loops. Yet, many of the proteins, which shape chromatin structure, bind only transiently. In those brief encounters, these dynamic proteins temporarily crosslink chromatin loops. While, on the average, individual crosslinks do not persist, in the aggregate, they are sufficient to create and maintain stable chromatin domains. Owing to the asymmetry in size and speed of molecules involved, this type of organization imparts unique biophysical properties-the slow (chromatin) component can exhibit gel-like behaviors, whereas the fast (protein) component allows domains to respond with liquid-like characteristics.

中文翻译：

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动态不对称性以及为什么染色质违反了简单的物理定义。

最近的实验已经证明核被染色质模制成稳定的交织环。然而，许多形成染色质结构的蛋白质只能瞬时结合。在短暂的相遇中，这些动态蛋白质会暂时交联染色质环。虽然平均而言，单个交联不会持续存在，但总体而言，它们足以创建和维持稳定的染色质结构域。由于所涉及分子的大小和速度不对称，这种类型的组织赋予了独特的生物物理特性-慢速（染色质）成分可以表现出凝胶状的行为，而快速（蛋白质）成分可以使结构域响应液体状的特性。