Understanding memory requires an explanation for how information can be stored in the brain in a stable state. The change in the brain that accounts for a given memory is referred to as an engram. In recent years, the term engram has been operationalized as the cells that are activated by a learning experience, undergoes plasticity, and are sufficient and necessary for memory recall. Using this framework, and a growing toolbox of related experimental techniques, engram manipulation has become a central topic in behavioral, systems, and molecular neuroscience. Recent research on the topic has provided novel insights into the mechanisms of long-term memory storage, and its overlap with instinct. We propose that memory and instinct may be embodied as isomorphic topological structures within the brain's microanatomical circuitry.

中文翻译：

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印迹细胞连通性：不断发展的信息存储基质。

理解记忆需要解释信息如何以稳定状态存储在大脑中。大脑中引起给定记忆的变化被称为印迹。近年来，“印迹”一词已被使用为由学习经验激活、具有可塑性并且对于记忆回忆来说是充分和必要的细胞。使用这个框架和不断增长的相关实验技术工具箱，印迹操作已成为行为、系统和分子神经科学的中心话题。最近对该主题的研究为长期记忆存储的机制及其与本能的重叠提供了新的见解。我们建议记忆和本能可以体现为大脑微解剖电路中的同构拓扑结构。