Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development. Monocytes bridge innate and adaptive immune responses and can affect the tumor microenvironment through various mechanisms that induce immune tolerance, angiogenesis, and increased dissemination of tumor cells. Yet monocytes can also give rise to antitumor effectors and activate antigen-presenting cells. This yin-yang activity relies on the plasticity of monocytes in response to environmental stimuli. In this review, we summarize current knowledge of the ontogeny, heterogeneity, and functions of monocytes and monocyte-derived cells in cancer, pinpointing the main pathways that are important for modeling the immunosuppressive tumor microenvironment.

中文翻译：

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肿瘤微环境中的单核细胞。

在过去的十年中，免疫疗法彻底改变了癌症的治疗方法。尽管如此，延长生存期仅限于相对较少的患者。癌症实施了一个多方面的免疫抑制网络，其性质在肿瘤发展过程中逐渐受到系统性和局部性提示的影响。单核细胞桥接先天性和适应性免疫反应，并可以通过多种机制来影响肿瘤微环境，这些机制可诱导免疫耐受，血管生成和增加肿瘤细胞的扩散。然而，单核细胞也可以产生抗肿瘤效应子并激活抗原呈递细胞。这种阴阳活动依赖于单核细胞对环境刺激的可塑性。在这篇综述中，我们总结了癌症中单核细胞和单核细胞衍生细胞的个体发育，异质性和功能的当前知识，