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Structural Mechanisms for Replicating DNA in Eukaryotes
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2021-06-21 , DOI: 10.1146/annurev-biochem-090120-125407 Ilan Attali 1 , Michael R Botchan 2 , James M Berger 1
中文翻译：
在真核生物中复制 DNA 的结构机制
更新日期：2021-06-22
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2021-06-21 , DOI: 10.1146/annurev-biochem-090120-125407 Ilan Attali 1 , Michael R Botchan 2 , James M Berger 1
Affiliation
The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.
中文翻译：
在真核生物中复制 DNA 的结构机制
被称为复制体的分子机器忠实而及时地复制 DNA 取决于一组不同的酶和支架因子以高度协调的方式协同工作。在不同构象和组成状态之间选择性变形的大型动态蛋白质-核酸组装体是这一关键细胞过程的基础。在本文中，我们讨论了最近的进展，概述了真核生物中复制体构建和进展的物理基础。
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