In this work, we present a novel modeling framework to investigate the effects of collateral circulation into the coronary blood flow physiology. A prototypical model of the coronary tree, integrated with the concept of Collateral Flow Index (CFI), is employed to gain insight about the role of model parameters associated with the collateral circuitry, which results in physically-realizable solutions for specific CFI data. Then, we discuss the mathematical feasibility of pressure-derived CFI, anatomical implications and practical considerations involving the estimation of model parameters in collateral connections. A sensitivity analysis is carried out, and the investigation of the impact of the collateral circulation on FFR values is also addressed.

在这项工作中，我们提出了一个新的建模框架来研究侧支循环对冠状动脉血流生理学的影响。冠状动脉树的原型模型与侧支血流指数 (CFI) 的概念相结合，用于深入了解与侧支回路相关的模型参数的作用，从而为特定 CFI 数据提供物理上可实现的解决方案。然后，我们讨论了压力衍生 CFI 的数学可行性、解剖学意义和涉及侧枝连接模型参数估计的实际考虑。进行了敏感性分析，并研究了侧支循环对 FFR 值的影响。